The structure of 5-amino-4-methyl-1-isoquinolinecarbaldehyde thiosemicarbazone hydrochloride, C12H14N5S+.Cl−
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چکیده
منابع مشابه
Effect of 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride on experimental brain tumors.
permits easy passage across the blood-brain barrier. Others have argued that since brain tumors do not possess a blood brain barrier, the lipid solubility of the nitrosoureas can play no robein their therapeutic effectiveness. We have tested ACNU, a water-soluble nitrosourea, for its chemotherapeutic effect in several animal brain tumor models and have compared ACNU to other more lipid-soluble ...
متن کاملEffect of 1-(4-Amino-2-methyl-5-pyrimidinyl)methyl-342-chloroethyl}. 3-nitrosourea Hydrochloride on Experimental Brain Tumors'
permits easy passage across the blood-brain barrier. Others have argued that since brain tumors do not possess a blood brain barrier, the lipid solubility of the nitrosoureas can play no robein their therapeutic effectiveness. We have tested ACNU, a water-soluble nitrosourea, for its chemotherapeutic effect in several animal brain tumor models and have compared ACNU to other more lipid-soluble ...
متن کاملLiver microsomal inactivation of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone as an inhibitor of ribonucleotide reductase.
Studies were carried out to determine the effects of preincubation of 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIQ) with hepatic microsomes on the ability of MAIQ to inhibit CDP reductase activity in vitro. An aliquot from the 100,000 x g supernatant fraction from this incubation was used in the CDP reductase assay. MAIQ incubated in the absence of microsomes inhibited CDP redu...
متن کامل5 - Amino - 3 - methyl - 1 , 2 , 4 - thiadiazole
An improved procedure for isolation of 5-amino-3-methyl-1,2,4-thiadiazole in pure form on a multi-gram scale without chromatography is reported. Its 1H and 13C-NMR and IR data are presented and previously published erroneous data corrected. The molecular structure is confirmed by X-ray diffraction which shows layers consisting of an elaborate two-dimensional hydrogen bonded network of molecules.
متن کاملHypothetical mechanism of therapeutic synergism induced by the combination of 6-thioguanine and 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride.
Comparative studies were carried out using various antimetabolites in order to determine whether the synergistic cellkilling effect on L1210 murine leukemia cells induced by a treatment combining 6-thioguanine (6-TG) and 3-[(4-amino2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitrosourea hydrochloride (ACNU) resulted from "complementary inhibi tion." The combinations of ACNU plus 5-fluoro...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section C Crystal Structure Communications
سال: 1984
ISSN: 0108-2701
DOI: 10.1107/s0108270184004510